eric topol twitter

Dr. Eric Topol discusses whether "pandemic is over" on with CNN anchor John Vauseso according to Joe

Scripps Research

Updated on Jan 12,2023

Dr. Eric Topol discusses whether "pandemic is over" on with CNN anchor John Vause

so according to Joe Biden the pandemic,is over here's the U.S president,speaking to 60 minutes,the pandemic is over we still have a,problem with covet we're still doing a,lot of work on it uh it's but the,pandemic is over,that's my pushback from both sides of,the Isles and White House aides have,scrambled to contain the Fallout one,saying there's no change in covert,policy and the public health emergency,remains in place through at least,October 13th but Republican leaders in,Congress say the president's remarks,will make approval for additional covert,relief funding more difficult,foreign,Executive Vice President of Scripps,Research he is also a cardiologist and,professor of molecular medicine uh good,to see you again,thanks John good to be with you so,looking at the numbers just the numbers,new cases continue to fall the number of,in-hospital deaths is down dramatically,from just over 15 percent when the Delta,variant was dominant slightly about five,percent now with Omicron the stock,market certainly took notice of what the,president said vaccine maker modernist,stock dropped amid President Biden,ceiling an end to the covert pandemic,yeah all these factors which support a,claim that the pandemic has done the,problem is it seems there's no,internationally agreed to definition or,criteria,um which sort of means it's open to,interpretation,right John well I think the best way to,consider if we're going to have the,pandemic uh pronounce is over it would,mean that we've contained the virus and,they wouldn't have four to five hundred,Americans dying every day for the last,six months and you wouldn't have,millions of new infections each month uh,and we have absolutely no way to counter,long covet transmission infections were,not set now to get containment of the,virus the virus is just keeping its,evolutionary Arc and it's getting more,formidable and we already know of some,tough tough variants on the horizon,which are already in the United States,uh over the one percent level and,they're going to grow exponentially,well one thing is for certain is that,the coronavirus isn't going anywhere uh,and this is from a CNN opinion piece as,we near the end of the third pandemic,year the accuracy of most,prognostications has been Dreadful the,coronavirus always seems to be several,steps ahead of our understanding despite,our best attempts and while we may have,the upper hand right now in terms of you,know vaccines and better treatments how,quickly could that change well the good,part here is that we're in dissent of,this really tough ba5 way we're going to,have several weeks even a couple of,months where it's going to be relatively,quiescent but we know there's going to,be another way following this the,inevitability of these even more immune,evasive variants we're staring at those,right now so our vaccines may not hold,up as well against variants that are,very different very challenging and we,aren't doing well in getting boosters at,least in Americans where half the rate,of boosters of every other rich country,in the world here and the most,vulnerable people the people over age 50,only one in four have had a force shot,which is essential it's life-saving,prevents hospitalizations and severe,covet so we're vulnerable not in the,next several weeks when things are,looking favorable it's after that and we,haven't gone after the things that could,really secure the exit of the pandemic,like the nasal vaccines like the pan,cervical virus vaccines we're just not,taking aggressive steps to get ahead of,the virus when we have the opportunity,this is interesting because uh the who,boss the director General essentially,said the pandemic was well the end of,the pandemic was in sight here he is,we have never been in a better position,to end the pandemic,we're not there yet,but,the end is inside,he had an extra element of caution there,but talking about the pandemic in terms,of winning a race or a wartime Victory,is that appropriate in the sense that,you know we probably need to learn to,coexist with the virus rather than,defeating it all out together right,right,um well there isn't any uniform,definition of what is the end of a,pandemic uh how is it defined it's only,really defined when you look backward,and you say hey we went several months,and things were you know in good shape,we had some outbreaks but you know we we,didn't lose a lot of people and we,didn't have monstrous number of,infections so you can't you can't make,the definition and Proclamation ahead of,it you have to you have to achieve that,uh the other thing Dr Tedros who is I,think right about the end is in sight,but that could be a year from now uh,it's in sight only because we've had,built an immunity wall from so many,infections so many vaccines and boosters,and of course as you mentioned John we,have better treatments than we had,before but the key here is to the point,when we achieve containment how many,more people are going to hurt get hurt,how many are going

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Judy Melinek Tells Eric Topol Why NRA Tweet Made Her Angry

Judy Melinek Tells Eric Topol Why NRA Tweet Made Her Angry

hello this is Eric Topol editor-in-chief,Mitsuki and I'm really delighted to have,the teams to speak with dr. judy melinek,who is forensic pathologists up in,Northern California she has a remarkable,background at Harvard College UCLA in,med school and she's been on the faculty,UCSF and now is associated with UC Davis,and Alameda Sheriff's Department so it's,been a very interesting week Judy and,maybe you start off with October 30th,the annals of internal medicine,publishes their public policy on guns,and Fire a very rational paper every,word of it now you are of course active,on social media twitter and you posted,something how did you get onto this,though there the what happened was is,that the annals of internal medicine,representing the position paper of the,American College of Physicians came out,with guidelines for internal medicine,practitioners about gun safety and it,turned out that the NRA had got a hold,of this and had tweeted out something,along the lines of self that somebody,should tell self-important doctors to,stay in their lane when it comes to gun,control and I wasn't the only one there,were multiple doctors on social media,and other healthcare professionals,including psychiatrists psychologists,nurses physical therapists chiropractic,physicians they all fought back saying,this is our lane in fact hashtag this is,our lane or this is my lane started,trending and I had woken up on Friday,morning and I had seen the NBC article,the day before but I haven't commented,on it and on Friday morning I was going,into work at the coroner's office I had,three cases one of which was a gunshot,wound case it was my second case that,week of gunshot wound death the first,one had been a homicide just a few days,earlier and I just lost it I mean I know,they say don't tweet angry but I tweeted,angry I wrote I'm trying to remember my,my exact quote it was something along,the lines and do you know how many,bullets I recover from cadavers,weekly or something I think corpses,weekly I said this isn't just my Lane,this is my effing highway and I went you,know showed off my phone went in the,morgue and then four hours later when I,got oh,did it ever you know I don't know I've,been on Twitter for nine years and I've,never seen a tweeted a 900,000 yeah but,what was unbelievable to me was how,generally positive I mean the thing is,is I got so many retweets and comments,from people in medicine and in health,care in general I got reactions from a,lot of victims of gun violence survivors,and they were all you know saying you go,girl,yeah did you get hostile responses in,general I got mostly positive responses,even from the people who disagreed with,me they were disagreeing respectfully I,was a little concerned that there may be,some trolls or some activists who would,potentially be threatening there was,only one kind of veiled threat along the,lines of you should be a cop so you can,get shot and I reported that to Twitter,and to their credit they took it down in,about 30 minutes so that was really,encouraging to me hey you know I think,the bottom line is that a lot of,responsible gun owners and NRA members,actually agree with doctors that we need,to do something they don't necessarily,agree with the NRA even though they're,members of the organization you know,they're the NRA still sought you know,they've been silent ever since this,tweet storm and I think that that says,something yeah one thing I've been,pointing out is that the NRA you know at,its inception when it was developed was,actually a gun safety organization and,was designed to train people how to use,gun safely and at some point they kind,of lost their vision and their mission,and I think that we can you know as,responsible physicians even and,especially physicians who are gun owners,or NRA members have a special,responsibility to speak up and get the,leadership to start coming in a,direction where we can all come to,agreements about,certain things and we there should be a,way there should be a balance where we,can respect people's second Amendment,rights to own weapons even individually,not just as a militia but still keep our,patients safe which means that when,people are having a mental health crisis,or are depressed or have exhibited,suicidal or homicidal ideations have,reached out or have easy access to,weapons and are starting to build an on,the material that other people should be,able to step in and use legal mechanisms,such as ER POS extreme risk protection,orders to step in and keep them and,other people safe yeah no question well,I want to applaud you you you among,others but you certainly attracted the,most attention of stood up it's really,important that you yeah good dad now one,of the things I want to touch on before,but before we do that that is activism,among positions as AB yes before we get,to that I want to just drill down a,little bit on the gun story so chapter,four hundred million guns in the US and,325 million people and we have over,twelv

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Covid. Capitulation: Where are We and What Can We Expect? | Eric Topol

Covid. Capitulation: Where are We and What Can We Expect? | Eric Topol

thank you thank you for paying attention,i know there's a lot of,interesting people here to talk to so,um,but but we want to cover a really,important topic uh,uh,our guest today eric topple knows more,about clovid if you followed him on,twitter than most people i know,and he looks both at the good and bad of,where we are,so,let's start there and hopefully we'll,have time for questions plenty of time,for questions too,um,eric let's start with where are we today,and,the both the good and the bad of where,we are and,right what what do you think people,don't know,sure well there's a lot we don't know,any of us could know because this virus,has been so unpredictable but,we're always seeing a lot better stead,than we were at the beginning,uh the death rate,not just here but around the world,um,has hit,the lowest point,since the very beginning of the pandemic,and is still heading down so we we know,from not just in vaccinations and,boosters,and prior infection immunity we've been,able to reduce the death toll,and,that's great on the,unfortunate thing is even in this,country we've already had near 200 000,deaths in this calendar year,so when you look at it,from the idea that it's not as fatal a,condition,we're still staring at long covey a very,important syndrome that still has not,been,demystified in many respects,and i think the biggest thing is that,we're seeing virus versions that have,increasing transmissibility,so,we were kind of,went a whole year of 2000,where,2020 where we didn't really see much,evolution the virus there was a minor,change from the ancestral strain to this,d614g and then all of a sudden it took,off with alpha delta and then the big,change of course was omicron the problem,is that as opposed to the prior,major variants alpha and delta,omicron has had these sub-variants that,are very troublesome,so,it wasn't just ba1 and 1.1 that really,hit this country they had 50 percent,more transmission than,delta but now we have another,30 from ba2 that we're in the midst of,and tomorrow the cdc will announce that,where the whole country is now dominant,with va 2 1 2 1. i wish we had better,names for these,and the problem is that's another 25,more transmissible,this transmissibility or contagiousness,is indexed to more immunoscape,so the virus is finding more and more,ways to,bypass our immune response and that,includes our vaccines that's the biggest,problem that we're not facing right now,there's this idea that with vaccination,and boosters,we're good to go and that unfortunately,couldn't be further from the truth,we have the problem where um,our transmission,prevention through the vaccines even,with two boosters is weak,it's porous,the term leaky is,probably appropriate but moreover we're,no longer at 95 percent prevent,prevention of death and hospitalization,we're actually now hovering between 80,maximum 85 with two boosters,and it's not lasting as long instead of,four to six months it may be three to,four months,so we're seeing chipping away at our,immunity wall,and the other thing that we have to look,forward to supposedly is this omicron,specific booster,supposed to be ready in july,the problem with that is it's a ba1,booster and we know that ba2 and ba2121,already have circumvented that so that,vaccine booster isn't gonna have likely,the impact that we'd like so we're,looking at a relatively sobering picture,of where we're headed because the virus,is still going to evolve,so why why has mutation accelerated,and is it mostly mutating in vaccinated,or,existing patients people with antibodies,to to covet,why the acceleration and why is it being,more resistant right,well the big acceleration um,notably was omicron that came as a,because it had some 60 mutations a,really hypermutated version of the virus,it came uh,in many ways as a a curveball in this,pandemic because while alpha and delta,had limited mutations,it wasn't anything like omicron and when,tracing that back the most likely source,was,an immunocompromised person,in southern africa,who basically had accelerated evolution,of the virus internally,and then that led uh to mark changes,which infected other individuals and,then it just took off,the problem is just in this country we,have seven million like,immunocompromised people and there are,tens of millions of those people,throughout the world,and so any one of them could have,accelerated evolution of the virus,the other problem you know is we have,other paths to get bad variants going,forward,we have,28 species,that the virus has become,a resident in and multiple spillovers,not just from mink,you may remember the hong kong,ba2 wave a horrible wave was linked to,pet hamsters that came into hong kong,from new from nether the netherlands,and then also we've had spillover from,white-tailed deer it's almost every,white-tailed deer in this country is,infected with the virus so we have all,these,potential uh ways from animal,reservoirs and then moreover we're,seeing all these co-infections now wher

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Dr. Eric Topol: The AI Path to More Accurate and Deeper Medicine

Dr. Eric Topol: The AI Path to More Accurate and Deeper Medicine

well everyone um,it is 1201 and i'd really like to,welcome,everyone to the uh the first of our,speaker series of the,the temerity center for ai research and,education and medicine,at the temporary faculty of medicine at,the university of toronto,the the center or t karem,is made possible by the generous,donation of the temerity family,and tcarim is an interdepartmental,center that serves as a focal point,for collaboration between healthcare,providers trainees researchers,computer scientists statisticians,engineers industry and so,many more to advance health through,artificial intelligence,our goal is to transform healthcare,through ai,just a quick note before we get into our,main event,this event is cpd accredited so in order,to obtain your cbd credit,please complete the evaluation form,which will be emailed to all attendees,following the event,and provide your name and email address,in the evaluation form,with that it is my distinct honor and,privilege,and pleasure to introduce dr eric topple,we're incredibly fortunate to have dr,topple kick off our speaker series,at the university of toronto uh dr toppo,needs no introduction,but uh i'll give a brief blurb dr toppo,is the founder and director of the,scripps research translational institute,and professor of molecular medicine,and also executive vice president of,scripps research,as a researcher he has published over,1200 peer-reviewed articles with more,than 280,000 citations so quite a bit of,influence,in academia as well as clinical medicine,he was elected,to the national academy of medicine and,is one of the top 10 most cited,researchers,in medicine his principal scientific,focus has been on genomic and digital,tools up to individualized medicine,in 2016 dr topple was awarded a 207,million dollar grant from the nih,to lead a significant part of the,precision medicine initiative which is a,prospective research program enrolling,one million participants in the us all,of this is in addition to his role as,principal investigator for a flagship 35,million,nih grant to promote innovation in,medicine,he was the founder of a new medical,school at cleveland clinic learner,college of medicine with case western,university,um the the accolades go on and on but,we're incredibly fortunate and delighted,to have dr eric,topol give us a talk on ai entitled,the ai path to deeper and more accurate,medicine dr topel it's a pleasure to,have you and thank you so much for,accommodating us,oh well thank you mohammed it's really a,pleasure for me to join you,and your colleagues uh university of,toronto,uh this is a really exciting time in,medicine,and i think we'll get into the,ai potential it's only beginning right,now,and it can make medicine more accurate,and it can make our connection to,patients and the patient doctor,clinician relationship,far more ideal,so the first thing i would say is for me,to come to the university of toronto is,a little ironic since you are the hub,the center of deep learning and uh,jeffrey hinton and jan mckeon and yoshio,benjio,the winners of the turing award in 2018,reflect that,but clearly um it really started there,so for me to come as uh you know i'm i'm,just a rookie in this space uh you are,the leader so,i'm delighted to have a chance to,interact with you and uh,uh we'll get into the problems that we,have at hand,the first thing is that the diagnostic,errors in the us,perhaps not as bad as in canada uh are,profound,uh we have more than 12 million a year,and,these are um so bad that,everyone will have at least one of these,in their lifetime national academy of,science review,or report uh interestingly time is a big,factor because,if if a clinician thinks of the,diagnosis within five minutes the,accuracy is very high,but it drops down markedly after that,so if it doesn't come to mind big,problem,and we have a lot of hubris and,arrogance among physicians because at,autopsy,those physicians who thought they were,absolutely certain of the cause of death,were actually wrong,forty percent of the time so,this is an excellent book uh by daniel,offrey who gets into this with her,patients and her experiences at bellevue,in new york,city and we do a lot of harm of course,it's unwitting,harm but nonetheless it's occurring,so muhammad mentioned the precision,medicine initiative in the u.s but,that's actually a very poor term,we don't want to be precise about making,mistakes that is making the same ones,repeatedly that would be a form of,precision we need accuracy,and precision so that's a long,term accuracy in precision medicine but,we can get there,and that's actually going to rely on,neural networks,and neural networks which,is a simulation of our brain human brain,but it obviously,it's very rough um parallels,it really relies on inputs the better,and more comprehensive,uh the inputs the better will be the,outputs as they flow through,these layers of artificial neurons,so just to give examples of how we know,accuracy can be markedly improved,i'll just co

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Dr Eric Topol: Preparing the healthcare workforce to deliver the digital future

Dr Eric Topol: Preparing the healthcare workforce to deliver the digital future

no-one's ever done something like this,that is taking this new set of tools,that are unquestionably having a,dramatic effect on Health Care's future,and to bring all the disciplines,together all the experts and start to,plan how to use these effectively and,what can we do to really benefit,patients with all these newfound,capabilities the fact that you can get a,warning on your wrist through your watch,that your heart rhythm isn't right or,you could get your potassium in your,blood through your watch these are some,things that we wouldn't haven't,anticipated so the fact that you can get,your genome sequence then you can get,your gut microbiome sequence there's so,many ways to understand each human being,like never before what it means is we,can get remarkably more productive that,we don't do math screenings but we know,who should be watched for whatever,particular conditions that in the future,we could prevent things like asthma,attacks and seizures and heart attacks,and strokes and far better management of,things like diabetes and high blood,pressure so there's all sorts of,opportunities of improving our workflow,and patient management reading scams,slides looking at skin lesions these are,all patterns that are better for,machines to process at high throughput,accurately and then have human clinical,oversight and that's where this is,landing this is a combination of doing,the things best that machines do that,also that clinicians can do there isn't,any question that over time and we're,talking not just immediately but in the,5 to 10 year time frame we're gonna see,some immense productivity improvement,so for example somebody was instead of,going into a regular hospital room they,could go home and be on sensors and be,continuously monitored with artificial,intelligent algorithms that's just one,example of how we're going to see,changes and when that happens think of,all the different people that are,affected for example we're going to need,more data scientists of which they're,relatively few and we'll have the types,of specialties which are going to be,very much supported through machine,learning in AI we may have less and and,if we ever get there remote monitoring,together we may have less hospital,personnel so we're gonna see dynamic,changes across the board over the years,ahead but there will be new areas that,will grow just as there are areas that,will see some reductions so this is,something that's bigger than the NHS it,really will be transformative that,eventually just a matter of time that,the patient will be truly the center and,clinicians will be rescued from the,despair of not being able to care for,patients well because they're so,burdened with so much keyboards and,administrative and all these other,things that divert them from what they,really want to do why they went into,healthcare and medicine in the first,place and then we obviously want to see,the productivity in these health systems,so each of these areas will eventually,be revolutionized over time maybe it'll,take 10 years 15 years 20 years and,we'll look back now in 2018 as this,thing rolled out is that we were able to,really nail it of what is the biggest,advantage of bringing all these tools,together,so for the staff on the NHS front line I,think this is a really exciting time for,them this is their chance to really get,involved in shaping the future of work,in the medical workforce and have a real,chance to have a say at how they can,improve their direct patient care giving,time provide more time for patients less,burdensome administrative work and using,advanced digital technologies to help,them do that we're not going to be,tearing up the rule book about how,medicine is practiced what we're going,to be doing is slowly rewriting and,editing the rules as we go along as,technology is slowly introduced into the,NHS and I think it's important for us to,be realistic in our predictions of the,impact on the workforce and how they're,going to change the way that we work,we need to start with the people at the,end of the spectrum where the high level,of health need and high level of digital,education sits because if we can get,this access to improved health care and,more digitally enhanced health care,right for those people then it will work,for everyone,all the way down the spectrum the risk,we need to avoid is getting it right for,the worried well who have become more,worried and we won't get the health care,improvements that we're looking for so,we've got to start with those people,increasing engagement in one's own,health and having apps and wearables and,things like that which make it easier to,do that well I think motivate people to,do so more if it is frankly more,convenient to do it because you don't,get a letter offering you an appointment,on a day that you can't make you ring up,to try and change you can't get any outs,on a phone it's nonsense if you've got,an actual app that can come and look at,your diary and say what this perso

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Science Communication Seminar Series: Eric Topol, M.D. (29 April 2022)

Science Communication Seminar Series: Eric Topol, M.D. (29 April 2022)

all right welcome everyone thanks for,joining us for our next installation of,our cycom seminar series,so i'll go ahead and introduce our,speaker now again,as most of you probably know he needs no,introduction but i'll go ahead and give,you one anyway dr eric topel,is a professor here in the molecular,medicine department the executive vice,president of scripps research and the,founder and director of the scripps,research translational institute he,completed his medical training at the,university of rochester followed by a,residency in internal medicine at uc san,francisco and a fellowship in,cardiovascular medicine at johns hopkins,university,prior to his tenure at scripps he was,the chairman of the department of the,cardiovascular,department of cardiovascular medicine at,the cleveland clinic where he also,founded the lerner college of medicine,he came to scripps in 2007 and since,then has led multiple initiatives and,grants dedicated to promoting innovation,in medicine including the use of genomic,and digital data as well as artificial,intelligence to individualize medicine,dr choppel is a practicing cardiologist,and a member of the national academy of,medicine he's published over a thousand,peer-reviewed articles as well as,multiple books on the future of medicine,and has shared his messages with many,audiences through a variety of media,outlets and today we're really excited,to have him with us,to share his insights and experiences on,science communication,so we're going to be structuring this,event a little bit differently from our,previous seminars um instead of a,traditional seminar format we're going,to be doing a q a so melissa and i have,some questions that will kick off,um with to dr topol and hear some of his,answers and experiences and this will,include some of the questions that you,all have submitted through the,registration,and we love audience participation so as,you guys think of questions um please,feel free to enter them in in the q a or,the chat and towards the second half of,the seminar we'd like to do a live q a,to actually have your questions be,answered by dr temple as well,so melissa would you like to,kick it off,sure,thank you so much dr topple for coming,in today um so we'd love to kick this,off by asking you,to tell us a little bit about your first,experiences in science communication and,specifically when you realize that,science communication was something you,really wanted to emphasize in your work,yeah well thanks uh it's great to be,with you and i know we'll have a fun,session today,um,yeah i think there was a real turning,point in my,career,and it happened,with this,madison biox that,turned out to have a real safety,issue with heart attacks and strokes it,was very popular,and what happened was,through work that i'd done with some,colleagues while i was at cleveland,clinic,we published a paper,that said you know there was this risk,and it was really the first paper to,call that out,and,we were attacked by the pharma company,responsible for that drug it was a,multi-billion dollar drug of course and,so any rate,i decided to write an op-ed in the new,york times,um,and uh this was in 2004 so you know a,number of years ago and i never had done,that before i never tried to reach the,public,uh and so when i did that um oh i also,learned that the new york times did,reserves to,re title your op-ed so they they had,vioxx vanquished and sounded really you,know anyway,um that was a turning point because i,started realizing that the audience for,us is not,the biomedical community but really the,public,uh and so that was a wake-up call and,that's what kind of led,ultimately to the idea of you know,writing books,you know and,writing lots of op-eds and kind of,turning,communication from what previously had,been you know textbooks and,peer-reviewed articles and you know,high science if you will,to a whole other genre which is hey you,know what we have an obligation,um,we were,getting supported by public funds,and we should be talking to the public,and,doing everything we can to help them and,so,ultimately about 12 years ago that's,kind of why i got onto twitter and,became a twitter addict i guess,um,because of that feeling that obligation,that you know the reach is just not,among,um our,micro world that it's a much bigger,mission and so i think it should be for,all of us,to be working on that because if we do,we can crowd out a lot of misinformation,disinformation,but unfortunately still today,uh scientists our physicians they're,reluctant to get involved in the,communication at large because they're,busy and because it's,got drawbacks that we'll talk about,so that's kind of the background i think,thank you for that i'm on that note,so how do you,manage some of this,like pushback or when you have all this,negative feedback coming in,how do you deal with that as you try to,communicate your science,yeah i know it's it's a daily,struggle intention because,you almost know you're going to get,peo

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Deep Medicine, Eric Topol, MD

Deep Medicine, Eric Topol, MD

let me ask you this what is the average,time that a doctor spends with a patient,in the United States for a visit oh it's,actually seven minutes it's pretty bad,yeah we should feel good because in,Japan and Korea it's down to two to,three minutes but anyway it's fast,medicine it's mistake Laden right and so,that's really what we have now we don't,understand the person we're seeing they,have lots of data nobody you know human,being can integrate all this data and we,need a new model in this new era,so that basically that concept was,originated back in the sixty and,interestingly this fellow ended balance,wrote the patient has to be understood,as a unique human being so we are all,unique but we haven't had the tools to,understand that uniqueness until now,that's what's so exciting about medicine,today so if you get National Geographic,this was the cover,last month the future of medicine and,it's actually a brilliant future I think,if we if we embrace it and we start to,acknowledge that each person is indeed,unique and we start this deep,phenotyping if you will understanding,them and it basically involves all these,different layers so if you think of a,Google map where you have that street,view the traffic view the satellite view,and now we all these views of a human,being and it goes from their external,features and their traditional medical,records to their Anatomy through scans,their physiology through sensors their,biologic layers their DNA and proteins,and their metabolites their microbiome,and their side chains of the DNA the,epigenome and then even their,environment which we can now quantify,with sensors for the first time so in,this review I had some years ago I,called it from pre womb to tomb because,we don't just assess somebody somebody,want to understand their uniqueness it,actually is done on the serial basis and,when I called it that my my old mentor,bill Kelly when I was at university,Michigan he saw that and he said Eric,you really blew it you should have,called it from lust to dust I said yeah,that would have gone over much better,would have been very interesting but,anyway these are ways to understand and,even being at a longitudinal basis so it,may be the DNA sequence is good for life,but a lot of these other things I need,to be done more often so the hottest,thing right now in genetics which is the,precursor the first realization that was,actually through MIT tech review it was,a cover of their 2018 breakthrough,technologies polygenic risk scores has,anybody had any polygenic risk score,here nobody well that's good that's good,anyway you'll be getting yours and,basically it's to know that you're going,to get a condition at least some,probability perhaps in your lifetime and,their actionable risk score so you can,prevent those conditions all right,so we have been a leader in this space,Alli torque Imani wrote a definitive,review article last May and basically,what this means is if you've had 23andme,how many had 23andme here okay well,while we're talking you can get your,risk score for heart disease ancestry,almost 30 million Americans have had,either ancestry or 23andme so they can,all get their risk scores for free,through our app basically it tells you,if you're at high risk for a critical,condition not just heart disease but we,are working to develop these for free,mobile apps that we have I'll show you,for all the major conditions type-2,diabetes,prostate cancer breast cancer colon,cancer we're finally at a time where we,have hundreds of genome variants which,can't be assessed for low cost for you,could actually develop a chip and do,this for $20 in fact and we can give you,a readout as to if you're at high risk,or moderate or low risk and in fact in,clinic I have patients who do it while,we're in clinic together,takes a short time so we developed this,app called my gene rank and it is the,only mobile app that does this it's only,for heart disease today it's both on iOS,and Android and soon it will be for,these other conditions so I did this and,I had I found out I had a risk score of,92 out of 100 for heart disease and I,have no heart disease in my family you,say how is that possible and the reason,that's possible is because this unique,blend of the variants you get from your,parents doesn't mean that there has to,be that family history so for heart,disease you know things like diabetes or,smoking or sedentary lifestyle and all,the other things and high cholesterol so,I started a statin and one of the most,powerful things about this is if you,have a high risk score you will benefit,from a stab but only two or three people,out of a hundred derive benefit from a,statin 95 to 97 people out of hundred,take statin every day the rest of their,lives many of you here to lower their,LDL and make a pretty lab value but,other than that it has no benefit so we,can do much smarter about using,medications this is an example of,actionable result of the score and,that's been validated in over a millio

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The Omicron Whirlwind: A Conversation with Eric Topol - The Current and Future State of the Pandemic

The Omicron Whirlwind: A Conversation with Eric Topol - The Current and Future State of the Pandemic

- Good afternoon.,Welcome to "Medical Grand Rounds.",Today is another "COVID Grand Rounds",and very excited to have an opportunity,to chat with Eric Topol.,Let me give you the ground rules first,,before we bring Eric on.,There they are.,You know these by now, Zoom in full-screen mode.,I'm gonna stop saying that.,I think if you don't know how to use Zoom by now,,we've got a big problem.,If you have questions type in the Q&A box.,I'll try to get to some of them.,The session will be recorded,and posted on YouTube tonight.,Overall, I think we've had over 3 million views,from our "Grand Rounds" over the past couple of years.,Closed captioning is available.,And if you want CME,,stay on at the end of the session and instructions,,and the barcode will be given to you at that point.,So, without further ado, let me turn to our special guest.,So, Eric Topol is Founder,and Director of the Scripps Research Translational Institute,and Senior Consultant,at the Division of Cardiovascular Diseases,at the Scripps Clinic in La Jolla, California.,He's got a long and incredibly impressive bio,,but I'll do the most important part first.,He was a Medicine Resident at UCSF.,He's also Editor-in-Chief of "Medscape" and "",He's published three best-selling books,on the future of medicine.,Highly recommended to any of you,interested in the future of medicine.,I hope you all are.,In 2018, '19, he led a commission,for the National Health Service in the UK,,looking at their future workforce,,genomics, digital medicine, and AI.,He's been principal investigator,on grants totaling at least a quarter of a billion dollars,,including leading a significant part,of the NIH's All of Us Precision Medicine Initiative.,He's a member of the AFCI, the AAP,,the National Academy of Medicine.,In 2012, "Modern Healthcare Magazine" deemed him,the Most Influential Physician Executive,in the United States.,Since COVID began,,his Twitter feed has become an essential resource,for individuals who wanna follow the pandemic,,and particularly emerging literature.,Eric has tweeted out all, anything that happens,that's new and important within minutes,,Eric seems to have it up.,And 600,000 followers have recognized that.,And I've told people,that if you were stuck on a desert island,and could follow only one person in COVID,,Eric would be the person.,So, Eric, why don't you come on?,Welcome.,It's great to have you here.,So, I'm gonna do a COVID sandwich.,We're gonna start with a couple of kinda personal questions.,Then it's gonna be pretty much all COVID,,which is I would assume most folks wanna hear about.,And then a couple of questions at the end,about kind of the future of medicine,and what this leaves us with,after hopefully this thing goes away.,So, let's start with a one,,a personal question, which is it's admission season.,We may have some applicants to our residency watching.,I'd love you to reflect on your at UCSF as a resident,and what it meant to you and your career.,- Well, Bob, first,,let me just say it's terrific to be with you.,And thanks so much for your kind intro.,As far as UCSF,,I think you know I have a incredibly fond memory,of my three years back in ancient times,,1979 to 1982 under the leadership of Holly Smith,and the inspiration of kinda Chatterjee,that totally shaped my career.,Those three years were probably,one of the three of the best years of my life.,We had our first baby.,My wife worked at the time, Mount Zion as a midwife.,And that time was just a hard to replace,over all the other times I've had,all the other phases of my career.,So, I don't know that there's a better UCSF residency,than UCSF medicine in the world.,I have recommended it throughout.,If you can get in, I know it's highly competitive,,remember of a particularly note,,I think, I don't know how it stands now,,but at Moffitt,,I don't know if it's still called Moffitt, I had-,- It's called Moffitt.,- Okay, 23 admissions one night.,That was, I got a lot of ribbing about it.,That was a very long night.,Of course, pretty hard to do full workups on 23 people.,But overall amazing experience.,And between the three places with the county and the VA,,just a phenomenal.,- Oh, great.,Thank you.,Yeah, well, just 23 admissions to an individual.,We don't allow anymore.,So, you'll be pleased to hear.,Let's talk just for a second about your Twitter feed.,So, I know you've been tweeting for a long time,,but clearly when COVID started,,you began to be quite prolific.,And in some ways your lane is these extraordinary detailed,annotated up-to-the-minute tweets,that capture what's going on in the literature,,and everybody is dependent on these.,And you tweeted last night,,like people ask you like about your team,and it sounds like we're looking at it.,You are it.,So, what made you wanna do that,and how's that experience been for you?,- Yeah, well, just to say from yesterday,,I was on a line with Carl Zimmer,about a PC's working on for the "New York Times.",And he asked me, "Tell

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